Nurses deliver infusion therapy to millions of patients in hospitals, home healthcare settings, long-term care facilities, outpatient clinics, and physicians’ offices annually. Nursing professionals perform many daily activities involving peripheral catheter insertion and safe delivery of intravenous (IV) fluids and medications. The use of vascular access devices and IV therapy are commonplace in the acute care setting. With that said, clinicians must take caution due to the potentially serious and fatal complications that can occur from inappropriate IV fluid or drug delivery.